16^TH Symposium on Ca²⁺- Binding Proteins and Ca²⁺ Function in Health and Disease.
Pucón-Chile
November 16-21, 2009

Nov. 16

14:00 – 16:00 Registration

16:00- 18:00
1^st Session: SPECIALIZED FUNCTIONS OF THE CALCIUM SIGNAL
Chair: Ernesto Carafoli

• Tuning sperm chemotaxis by calcium burst timing.
  Alberto Darszon (Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, México).
• The biphasic increase of PIP2 in the fertilized eggs of starfish: New roles for actin polymerization and Ca⁺².
  Luigia Santella (Stazione Zoologica Anton Dohrn Villa Comunale, Napoli, Italy).
• Phosphoregulation of inositol 1,4,5-trisphosphate receptors by cyclic nucleotide dependent kinases.
  David Yule (Department of Pharmacology and Physiology, University of Rochester, Rochester NY, USA).
• Inositol 1,4,5-trisphosphate receptor regulation in life and death.
  Jan B. Parys (Lab. Molecular and Cellular Signaling, K.U.Leuven, Belgium).

18:30 Ebashi Lecture
Chair: Enrique Jaimovich

• IP₃ ligand gated Ca²⁺ channel: structure and its variety of physiological and pathological functions.
  Katsuhiko Mikoshiba (Lab.for Developmental Neurobiology, RIKEN, BSI and JST ICORP-SORST).

20:00 Dinner

Nov. 17

9:00
2^nd Session: STRUCTURAL BIOLOGY OF CALCIUM SIGNALING
Chair: Sara Linse

• The structure and function of Ca²⁺ -ATPases.
  Maike Bublitz (Center for Structural Biological, University of Aarhus, Denmark).
• Dual Ca²⁺ sensors regulate gating of human cardiac voltage gated Na⁺ channel Na_V1.5.
  Walter Chazin (Departments of Biochemistry, Chemistry, and Anaesthesiology and Center for Structural Biology, Vanderbilt University, Nashville, TN USA).
• Structure and function of STIM proteins as an initiator of store operated calcium entry.
  Mitsu Ikura (Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada)
• Calmodulin and its interactions.
  Sara Linse (Biophysical Chemistry, Lund University).

11:00 Coffee break

11:30 Plenary Lecture
Chair: Cecilia Hidalgo

• The multiple roles of calcium in biological systems.
  Ernesto Carafoli (Venetian Institute of Molecular Medicine, University of Padova, Italy).

13:00 Lunch

14:30
3^rd Session ALACF Session Calcium crosstalk between endoplasmic reticulum and plasma membrane
Chair: Javier García-Sancho

• Revealing the structure of a Ca²⁺-dependent K⁺ channel using fluorescence.
  Ramón. Latorre (Centro de Neurociencias Celular y Molecular Valparaíso, Valparaíso, Chile).
• TRPC-STIM1-Orai1 ternary complex in capacitative calcium entry).
  Ginés  Salido (Research Group, University of Extremadura, 10071-Cáceres, Spain).
• The ecto-enzyme CD38 is a mammalian NAADP synthase which couples receptor activation to Ca²⁺ mobilization from lysosomes.
  José Cancela (CNRS, Institut de Neurobiologie Alfred Fessard – FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire, France).
• Regulation of Ca²⁺ signals by intracellular organelles.
  Javier García-Sancho (IBGM, Universidad de Valladolid & CSIC, Valladolid, Spain).

17:00 Coffee break

17:30
4^rd Session: CALCIUM, CELL DEATH AND DISEASE
Chair: Paul Allen

• Roles of calcium-stimulated adenylyl cyclases and CaMKIV in chronic pain and fear.
  Min Zhuo (Department of Physiology, University of Toronto, Toronto, Canada). 
• Calcium and the slow channel syndrome.
  Jordi Molgó (CNRS, Institut de Neurobiologie Alfred Fessard – FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire, France).
• The crucial importance of type 2 and 3 IP₃ receptors for the initiation of acute pancreatitis.
  Oleg Gerasimenko (Physiology Dept. Liverpool, University).
• Alterations in RyR/DHPR interactions associated with malignant hyperthermia.
  Paul Allen (Brigham and Women’s Hospital, Harvard Medical School, Boston MA USA.

20:30 Dinner

Nov. 18

9:00
5^th Session
CALCIUM ENTRY MECHANISMS
Chair: Ramón Latorre

• TRP channels: from sensory signaling to neurodegenerative disease.
  Craig. Montell (Department of Biological Chemistry, The Johns Hopkins University School of Medicine).
• Orai channel alchemy – changing CRAC into ARC.
  Trevor Shuttleworth (Department of Pharmacology and Physiology, University of Rochester Medical Center).
• Different calcium entry mechanism for different responses.
  Alan Neely (Centro de Neurociencias de Valparaíso. Facultad de Ciencias, Universidad de Valparaíso, Valparaíso-Chile).

10:30 Coffee break

11.00 – 12.30 POSTER SESSION I: Calcium and Cell Function

Coordinators:
Mariana Casas
Nora Riveros

Panels 1-16

POSTER SESSION II: Calcium and Disease
Coordinators:
Mariana Casas
Nora Riveros

Panels 17-23

13:00 Lunch

14:30
6^th Session: ORGANELLE –MEDIATED CALCIUM SIGNALING
Chair: Tullio Pozzan

• Mitochondria, calcium and cell death by apoptosis or necrosis.
  Rosario Rizzuto (Dept. Biomedical Sciences, University of Padua, Italy).
• Molecular basis of store-gated Ca²⁺ release.
  Wayne Chen (Dept of Physiology and Pharmacology, University of Calgary, AB, Canada).
• Redox modulation of RyR activity: a key feature of cellular calcium signaling?.
  Cecilia Hidalgo (Centro FONDAP de Estudios Moleculares de la Célula e Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile).
• A molecular dissection of the NAADP signalling pathway and its role in health and disease.
  John Parrington (Department of Pharmacology, University of Oxford, Oxford, United Kingdom).

17:00 Coffee

17:30
7^th Session: NUCLEAR CALCIUM AND THE REGULATION OF GENE EXPRESSION
Chair: José Naranjo

• Nuclear translocation of transcriptional repressor DREAM.
  José Naranjo (Centro Nacional de Biotecnología, CNB, Madrid, España).
• Actin and myosins in the nucleus: Old functions for really old proteins.
  Primal de Lanerolle (Department of Physiology and Biophysics, University of Illinois at Chicago).
• Different patterns of calcium channel signaling to the nucleus.
  Richard W. Tsien (Department of Molecular and Cellular Physiology, Stanford University, Stanford CA 94305 USA).
• On the mechanisms for excitation-transcription coupling in skeletal muscle.
  Enrique Jaimovich (Center for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile).

21:00 Dinner

Nov. 19

9:00
Joint Session with Argentine Physiological Society. CALCIUM SIGNALING IN THE HEART
Chair: Alicia Mattiazzi, Co-chair: Leticia Vittone

• Increased automaticity in mice with genetic ablation of sorcin, a Ca-binding protein that modulates excitation-contraction coupling in heart.
  Héctor Valdivia (Department of Physiology, University of Wisconsin Medical School, Madison, Wi, USA).
• Genetic and acquired defects in ryanodine receptor channels and cardiac arrhythmia.
  Sándor Györke (The Ohio State University, Columbus, OH).
• Role of intracellular Ca²⁺ release on electrical excitability: New clues for ventricular arrhythmias
  Ariel. Escobar (University of California, Merced School of Engineering 5200 North Lake Rd Merced).
• CaMKII protects the heart from intracellular acidosis but is deleterious upon returning to normal pH.
  Cecilia Mundiña-Weilenmann (Centro de Investigaciones Cardiovasculares. Facultad de Medicina. UNLP, La Plata. Argentina).

11:00 Coffee

11:30
9^th Session: CALCIUM AND DISEASE
Chair: David. H. MacLennan

• Calcium, mitochondrial stress and Parkinson’s disease.
  James D. Surmeier (Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 USA).
• ER-Mitochondrial Calcium Signaling and Cell Death.
  György Hajnóczky (Thomas Jefferson University).
• Lesion Formation in Skeletal Muscles of the Ryr1^I4895T/+ Model of Central Core Disease.
  David. H. MacLennan (University of Toronto, Toronto, ON, Canada).

13:00 Lunch

14:30
10^th Session PUMPS AND EXCHANGERS
Chair: Reinaldo. DiPolo

• The activity of the Na⁺/Ca²⁺ exchanger largely modulates the Ca²⁺i signal induced by a hypo-osmotic stress in rat cerebellar astrocytes.
  Reinaldo DiPolo (Laboratorio de Fisiología Celular. Centro de Biofísica y bioquímica. IVIC. Caracas Venezuela).
• Transductional and transcriptional factors regulating NCX gene products in brain ischemic preconditioning and postconditioning.
  Lucio Annunziato (Division Pharmacology, Department Neuroscience, School of Medicine, “Federico II” University, Naples, Italy).
• Ca²⁺ signalling defects in hearing loss: role of the plasma membrane Ca²⁺-ATPase.
  Marisa Brini (Dept. of Experimental Veterinary Sciences and Dept. of Biochemistry, University of Padova, Viale G.Colombo 3 35131 Padova Italy).
• Role of calcium signalling in prostate cancer
  Natalia Prevarskaya (Laboratory of Cell Physiology, INSERM U800, University of Lille1, France).

17:00 Coffee

17:30
11th Session WORKSHOP (Calcium in Alzheimer)
Chair: Nibaldo. Inestrosa

• Wnt and calcium signaling in synaptic differentiation and Ab-neuroprotection: Role of CaMKIV.
  Nibaldo C. Inestrosa (Centro de Envejecimiento y Regeneración (CARE), Centro de Regulación Celular y Patología “Joaquín V Luco” (CRCP), MIFAB, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile)
• Aβ ion channels mediate the Alzheimer's Aβ peptide-induced acute calcium response in cells.
  Nelson Arispe (Department of Anatomy, Physiology and Genetics. School of Medicine. Uniformed Services University of the Health Sciences. Bethesda, Maryland USA).
• Molecular mechanisms and consequences of FAD-associated exaggerated Ca²⁺ signaling.
  Kevin Foskett (Department Physiology, University Pennsylvania, Philadelphia, PA USA).
• Presenilins, neuronal calcium signaling and pathogenesis of Alzheimer’s disease.
  Ilya Bezprozvanny (UT Southwestern Medical Center at Dallas, Dallas, TX, USA).

19.30 – 20.30 POSTER SESSION III
CALCIUM AND SIGNAL TRANSDUCTION Panels #24-#36
Coordinators: Alejandra Espinoza- Sonja Buvinic

POSTER SESSION IV
CALCIUM TRANSPORT Panels # 37- #48
Coordinators: Alejandra Espinoza- Sonja Buvinic

21:00 Special Dinner

22:30 Dance

Nov. 20

9:00
11^th Session: EMERGING TOPICS IN CALCIUM SIGNALING
Chair: Martha Cyert

• Determinants of substrate recognition by calcineurin.
  Martha S. Cyert (Dept. of Biology, Stanford University, Stanford, CA 94305-5020, U.S.A). 
• Function of Polycystin 2 (TRPP) in Polycystic Kidney Disease (PKD).
  Barbara E. Ehrlich (Departments of Pharmacology and Cellular & Molecular Physiology Yale University School of Medicine).
• Roles of intracellular Ca²⁺ release in central nervous system functions.
  Masamitsu Iino (Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan).
• PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium induced cell death
  Andrey Y Abramov (Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK)

11:00 Coffee

11:30
SAFIS Workshop: CALCIUM-DEPENDENT PROCESSES IN THE HEART
Chair: Cristina Arranz (Argentina) Co-chair: Margarita Salas (Argentina)

• CaMKII dependent phosphorylation of the cardiac ryanodine receptor sensitizes the channel to luminal Ca²⁺ activation.
  Wayne Chen (Dept of Physiology and Pharmacology, University of Calgary, AB, Canada).Canada):
• The apoptotic signaling cascade of angiotensin II.
  Martin Vila-Petroff (Centro de Investigaciones Cardiovasculares. Facultad de Cs. Médicas, UNLP. 60 y 120 La Plata, Argentina).
• The mechanism of negative staircase in rodent myocardium.
  Rosana Bassani (Center for Biomedical Engineering and Dept. Biomedical Engineering/FEEC, University of Campinas (UNICAMP), Campinas, SP, Brazil).
• The starling law of the heart and the Anrep phenomenon.
  Gustavo Pérez (Centro de Investigaciones Cardiovasculares, Facultad de ciencias Médicas de la Plata, Universidad Nacional de La Plata).
• Heart failure, arrhythmias, and ca-signaling in cardiac sarcomeres.
  John Solaro (University of Illinois at Chicago USA).

13:30
Free afternoon, excursion

Nov 21 Departure